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SASRIN super acid sensitive resin

Carrier Chloromcthyl-PS/DVB (SASRIN Super Acid Sensitive Resin)... [Pg.179]

Another highly acid-labile resin, 5, known as SASRIN (super-acid-sensitive resin) [29-31], has also found widespread application, and other, even more acid labile, handles and resins are available [32,33]. Cleavage of peptides from 5 can be accomplished in high yield by treatment of peptide-... [Pg.380]

HMPB resin, an aminomethyl polystyrene resin acylated with 4-hydroxymethyl-3-methoxyphenoxybutyric acid cleavable by extremely mild acidolysis similar to SASRIN (super acid-sensitive resin). Detachment of the final product, even in form of the frilly protected peptides, is achieved with dilute acid (1% TFA/dichloromethane) to yield peptide... [Pg.168]

EDC FDPP Fmoc HOBt LiHMDS MAMP MCPBA MeOPEG NCA NMP PAL PASP PBP PEG SASRIN TEA TFA TMAD N-Ethyl-N - [ 3 - (dimethy lamino)propy 1] -c arbodiimide hydrochloride Pentafluoro phenyldiphenyl phosphate 9 -Fluoreny lme thoxy c arbony 1 Hydroxybenzotriazol Lithium hexamethyldisilazane Merrifield, alpha methoxy phenyl resin w-Chloroperbenzoic acid Methoxy polyethylene glycol /V-Carboxv a-aminoacid anhydride /V - M e t h v 1 pyrrol i do n e Peptide amide linker Polymer assisted solution phase Penicillin-binding proteins Polyethylene glycol Super acid sensitive resin Triethylamine Trifluoroacetic acid Tetramethylamine azodicarboxylate. [Pg.262]

The Wang linker 1.1 (57) is a very popular choice that is based on ap-alkoxybenzyl alcohol moiety. It is typically cleaved by trifluoroacetic acid (TFA)-DCM 1/1 in 30 min at room temperature (rt) to produce carboxylic acids or alcohols. Two slight modifications to this linker have produced the super-acid-sensitive resin (SASRIN)... [Pg.10]

SASRIN resin (super acid sensitive resin)... [Pg.689]

Other highly acid-labile functionalized solid supports and handles incorporate one or two additional electron-donating substituents, such as methoxy groups in 4-alkoxybenzyl alcohol-base-resins. Among these systems, SASRIN resin (super acid sensitive resin, 11),[4 " ] 4-(4-hydroxymethyl-3-methoxyphenoxy)butanoic acid (HMPB, 12),t4 and 2,4,5-trichlorophenyl 5-(4-hydroxymethyl-3,5-dimethoxyphenoxy)valerate (13)f4 l handles are the most widely used. [Pg.691]

See other pages where SASRIN super acid sensitive resin is mentioned: [Pg.185]    [Pg.760]    [Pg.231]    [Pg.262]    [Pg.464]    [Pg.337]    [Pg.337]    [Pg.262]    [Pg.302]    [Pg.4]    [Pg.185]    [Pg.760]    [Pg.231]    [Pg.262]    [Pg.464]    [Pg.337]    [Pg.337]    [Pg.262]    [Pg.302]    [Pg.4]    [Pg.139]    [Pg.140]    [Pg.453]    [Pg.421]    [Pg.359]    [Pg.17]   
See also in sourсe #XX -- [ Pg.172 , Pg.179 ]



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Acid sensitive

Acidic resin

Acidity super

Resinic acids

SASRIN

SASRIN resin

Super acids

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