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Sarin albumin binding

Sarin and soman have been shown to bind to a tyrosine residue present in a blood protein (51). The precise site of this residue has not yet been confirmed but it is associated with the albumin fraction. An LC/ESI/MS/MS (triple quadrupole) method was developed for its detection after digestion of the albumin fraction with Pronase and clean up on a C18 SPE (solid-phase extraction) cartridge. A... [Pg.304]

These examples show that OPs can bind covalently to albumin under physiological conditions, and that the resultant adducts are relatively stable. OP-albumin adducts could therefore be useful as biomarkers of OP exposure. In addition, unlike cholinesterases, the soman-albumin conjugate does not age (Li et al, 2008a), making it possible to discriminate between sarin and soman exposure. OP-albumin adducts have not yet been reported in humans exposed to OPs. [Pg.852]

See other pages where Sarin albumin binding is mentioned: [Pg.760]    [Pg.771]    [Pg.1054]    [Pg.141]    [Pg.822]    [Pg.835]    [Pg.835]    [Pg.864]    [Pg.883]    [Pg.892]   
See also in sourсe #XX -- [ Pg.771 ]



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