Sarcomeres crossbridge cycle

Clearly there is a still much to learn about the contractile mechanism, force production, the strain dependence of the crossbridge cycle and, indeed, how force and movement are actually generated. As shown in Squire et al., Granzier and Labeit, Brown and Cohen, and Geeves and Holmes (all in this volume), and in this article, a great deal is already known about muscle structure and function. However, there is also little doubt that the sarcomere still has some major surprises in store for us. 

---