Santolina triene

Chrysanthemic acid (126), artemesia ketone (127), santolina triene (128) and lavandulol (129) are representatives of irregular monoterpenes which, unlike other regular monoterpenes, are not derived directly from geranyl pyrophosphate (59). By contrast to the regular... 

The anti-inflammatory effect of the EO from the leaves of indigenous Cinnamomum osmophloeum Kaneh. (camphor tree, Lauraceae) was studied by Chao et al. (2005). Twenty-one components, among which the monoterpenes 1,8-cineole (17%) and santolina triene (14.2%) and the sesquiterpenes spathulenol (15.7%) and caryophyUene oxide (11.2%), were analyzed as main constituents. In the anti-inflammatory assay it was found that the EO exerted a high capacity to suppress pro-IL-l i protein expression induced by LPS-treated J774A.1 murine macrophage at dosages of 60 xg/mL. Additionally, IL-lp and IL-6 production was reduced at the same dose. The TNE-a production could not be influenced by this dose of the EO. 

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