Sample Preparation for Static Headspace Extraction

The ease of initial sample preparation is one of the clear advantages of static headspace extraction. Often, for qualitative analysis, the sample can be placed directly into the headspace vial and analyzed with no additional 

One example of suspending or dissolving a solid in solution is seen in USP method 467, which provides an approach for the analysis of methylene chloride in coated tablets. The sample preparation procedure calls for the disintegration of 1 g of tablets in 20 mL of organic-free water via sonication. The solution is centrifuged after sonication, and 2 mL of the supernatant solution is transferred to a HSAS vial and then analyzed by HSGC [12]. 

In static headspace extraction, sample preparation for liquid samples is usually quite simple—most often, the sample can just be transferred to the headspace sample vial and sealed immediately following collection of sample to minimize storage and handling losses [13], 

---