Salvia divinorum salvinorin

Keywords. Salvia divinorum Salvinorin A Psychoactive plants Psychoactive compounds... 

Keywords Hallucinogen high performance liquid cluoniatography Mexican sage psychotropic diterpene Salvia divinorum salvinorin A. 

Keywords - diterpene, divinorin A, hallucinogen. Salvia divinorum, salvinorin A... 

The active principle of Salvia divinorum, salvinorin A, is derived from the leaves of the plant. Chemically, salvinorin A is a neoclerodane diterpene, one of a group of nitrogen-containing terpene compounds that have psychotropic properties. Two other such compounds are tetrahydrocannabinol and absinthe. Purified salvinorin A can be obtained from an ether extract of the leaves, which is then concentrated by chromatography and repeated crystallization. 

The discovery of a potent and selective K-opioid receptor agonist compound, salvinorin A (54), a hallucinogenic neoclerodane diterpenoid from Salvia divinorum Epling and Jativa, has created particular interest in recent years, since it is the first nonnitrogenous compound found to demonstrate this type of activity. 

Daniel Siebert, the host of this web site and the founder and moderator of the original Salvia email discussion forum (now the Sagewise mailing list), for his contributions and support of this project, his research papers on Salvia divinorum and salvinorin A, his attempts to keep the focus of discussions on Salvia, his constructive criticism, and for all the valuable information he has shared. 

Used irresponsibly. Salvia divinorum and salvinorin A can be dangerous. If you decide to try this herb, or any preparation containing salvinorin A, it is your responsibility to take proper precautions so that you do not harm yourself or others while under its influence. Neither the author of this FAQ, nor any individual who contributed to its creation or posting, or who submitted material contained herein, nor the web site host, nor anyone but you yourself is responsible for your actions or their consequences. 

A. Salvia divinorum is a plant used for its psychoactive effects. Given the right dose, individual, set and setting, it produces a unique state of divine inebriation which has been traditionally used by Mazatec healers. This inebriation is quite different from that of alcohol. S. divinorum is both similar to, and different from, other drugs that affect the brain and behavior. In many ways Salvia divinorum is a unique magical herb. Salvia (and the salvinorin it contains) is very difficult to categorize pharmacologically. 

A. The Sase Wisdom Salvia divinorum Shop is a great source for live cuttings. Salvia divinorum leaves, standardized extracts. Sage Goddess Emerald Essence, etc. A detailed listing of other suppliers can be found in "Salvia divinorum and Salvinorin A The Best of the Entheogen Review 1992-1998". Another good resource is "The Psychedelic Resource List" by Jon Hanna. 

Q. How long can I store Salvia divinorum leaves or salvinorin A fortified leaf without them loosing potency ... 

Q. Do I need a special kind of lighter to smoke salvinorin A fortified leaf or Salvia divinorum leaves ... 

A. An ordinary lighter or match is quite hot enough to vaporize salvinorin A and should be quite adequate for smoking salvinorin A fortified leaf products. An extra hot flame, such as that produced by a micro-torch, will simply cause more rapid vaporization and combustion. This can be an advantage when smoking plain Salvia divinorum leaves, because it is usually necessary to smoke a relatively large amount of leaf in a short amount time to achieve strong effects. 

A. Possibly. A substance known as divinorin C has been recently reported by Valdes et. al to be behaviorally active in mice at even lower dosage than salvinorin A. Divinorin C is closely related chemically to salvinorin A and is present in his Salvia extracts in 1/9 the concentration of salvinorin A. It may contribute to the psychoactive effects of Salvia leaves. Divinorin C has never been bioassayed in humans due (among other reasons) to the difficulty in preparing pure samples in significant quantity for such bioassay. A few other salvinorin like compounds are known to be present in Salvia and may also contribute to its psychoactivity. However, salvinorin A is the only Salvia divinorum compound presently known to be psychoactive in humans. 

If you want to learn about salvinorin, its effects and its chemistry a good place to start is J Psychoactive Drugs 1994 Jul 26(3) 277-283 Salvia divinorum and the unique diterpene hallucinogen, Salvinorin (divinorin) A. Valdes LJ 3rd. 

Siebert DJ. 1994. Salvia divinorum and salvinorin A new pharmacologic findings. Journal of Ethnopharmacology. June 43(l) 53-56. 

Ortega, A. etal. 1982. Salvinorin, a new trans-neoclerodane diterpene from Salvia divinorum (Labiatae). Journal of the Chemical Society Perkins Transactions. 1 1982 2505-2508. 

A No. Salvia divinorum is a legal herb that does not lend itself to abuse. Therefore, there has been no incentive to develop tests for it. The active principal, salvinorin A, is not chemically similar to any illegal drug and will not produce a false-positive on drug tests that test for illegal drugs. 

Hard extracts. These can be prepared by a more complicated use of two solvents in a separatory funnel, one to remove the oils and waxes but leave the salvinorin and the other to dissolve the salvinorin. A hard extract could be ground and used as a powder. No Salvia divinorum hard extracts are being sold. Such a hard extract might be suitable for vaporization or use as a nasal snuff. Instructions for making a hard extract are not included in the FAQ. 

A. The best place to start is at the Salvia divinorum Research and Information Center home page. There you will find links to many related sites. To discover more, just use your favorite search engine to search on terms like Salvia , Salvia divinorum , Mazatec , and salvinorin One of the best search engines to use is google.com. 

Q. Where can I learn about the history of Salvia divinorum and salvinorin ... 

Ott, J. 1995. Ethnopharmacognosy and Human Pharmacology of Salvia divinorum and salvinorin A. Curare. 18 (1) 103-129... 

Images of Salvia divinorum plants and the chemical structure of salvinorin A. 

At present (Sept. 29, 2000), neither Salvia divinorum nor its active principal, salvinorin A, are controlled substances anywhere in the world. It is completely legal to grow, buy, and sell Salvia plants or leaves. 

Pharmako/Poeia, assigns Salvia divinorum to a unique pharmacological class, which he calls "existentia." This term alludes to the philosophical illumination salvia seems to shine on the nature of existence itself. Daniel Siebert has proposed the term enchantogen—3. neologism, meaning "a substance that produces enchantment." No one knows how salvinorin works in the brain. We do know it works differently than any other known psychoactive substance. 

There is now a commercially available Salvia tincture. It is marketed by Daniel Siebert as "Sage Goddess Emerald Essence ." This fluidextract of Salvia divinorum is intended to be kept in one s mouth until its salvinorin content has been absorbed. While it can be taken undiluted, it is quite irritating to the mouth if taken in this way. The irritation is due to its high alcohol content. It is better to take it diluted with hot water. The amount of alcohol taken even in a large dose of the... 

Immagini delle piante di Salvia divinorum e della struttura chimica di salvinorin A. 

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