Salinispora sporolides

Buchanan GO, Williams PG, Feling RH, Kauffman CA, Jensen PR, Fenical W (2005) Sporolides A and B Structurally Unprecedented Halogenated Macrolides from the Marine Actinomycete Salinispora tropica. Org Lett 7 2731... 

Sporolides A and B were isolated in 2005 from a fermentation broth of a strain of the marine actinomycete Salinispora tropica. The structures 377 and 378 and the absolute stereochemistries for sporolide A and sporolide B were elucidated using a combination of NMR spectroscopy and X-ray crystallography. Unformnately, the sporolides, tested for antitumor and antibacterial activity, were inactive (Figure 3.130) [470]. 

Recent application of PKSE data sets and the noted PCR-based strategy has revealed that the biosynthetic gene cluster for sporolides A and B contains two loci encoding PKSEs 13). Produced by Salinispora tropica, sporolides A and B do not contain enediynes per se (Figure Ic). Rather, each substance contains a tricyclic motif that is proposed to originate biosynthetically from a transient... 

Salinispora tropica (N PI-0052) Sediment (-1 m) Bahamas Sporolides Salinosporamides A-C Salinosporamides D-j Anti proteal ide Cytotoxics, inhibitors of proteasome Buchanan et al., 2005 Williams et al., 2005 Beer eto/., 2007 Reed et al., 2007 Udwaryeto/., 2007 Manam et al., 2009... 

Buchanan, G,0 Williams, P,G Feling, R.H., Kauffman, C.A, Jensen, P.R., and Fenical, W, (2005) Sporolides A and B Structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica. Org. Lett., 7, 2731-2734. 

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See also in sourсe #XX -- [ ]

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