Salicylic acid gel

Premix items 1-4. Add item 5 with low-shear mixing until homogenous. 

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A client asks for a salicylic acid gel he is buying for his mother for the removal of corns and calluses. 

Note The reagent was not particularly sensitive for acids. On cellulose layers the detection limit was ca. 1 pg (salicylic acid > 5 pg) and on silica gel layers it was 5 pg (fumaric acid ca. 1 pg). 

Detection and result The chromatogram was dried in a stream of warm air for 10 min, immersed in the reagent solution for 3 s and then subjected to intense UV radiation (high pressure lamp, A = 365 nm) for up to 10 min. Terephthalic (hRf 0 - 5), pimelic (hRf 55), suberic (hRf 60), sebacic (hRf 65 — 70) and benzoic acids (hRf 70 — 75) together with sorbic, malic, adipic, citric, tartaric, lactic and fumaric acids only exhibited a reaction on silica gel layers at higher concentrations. 4-Hydroxybenzoic, salicylic and acetylsalicylic acids fluoresced light blue after irradiation. The detection limit per chromatogram zone was 0.5 pg for salicylic acid and more than 5 pg for benzoic acid. 

Fig. 14.7a, b. Malar melasma before and after combined peeling with 25% salicylic acid and 10% TCA gel... 

PVA/p-CD/salicylic acid -p-CD forms inclusion complexes with different water soluble substances i.e. salicylic acid - The drug release from the PVA/p-CD gel is nearly proportional to time 235... 

Partial Purification of SA-GTase. Proteins extracted from oat roots Incubated for 20 h in salicylic acid were separated by salt precipitation and gel exclusion and anion exchange chromatography (Table IV). A 5 -fold purification of the SA-GTase was achieved with this... 

Fig. 4 Elution profiles for (A) propranolol (a), promethazine (b), and chlorprom-azine (c) applied separately on a 5-mm ILC column containing cytoskeleton-depleted red blood cell membrane vesicles entrapped in dextran-grafted agarose gel beads (1.4 /amol phospholipid, 0.5 mL/min) and (B), from left to right, acetylsalicylic acid, salicylic acid, warfarin, and pindolol on a capillary continuous bed containing liposomes immobilized by use of C4 ligands (1.0 /xmol phospholipid, 10 /xl./min). The elution volumes in the absence of lipid are shown (a0, b0, and c0, and the arrow, respectively). (Part A is reprinted with permission, with slight modification, from Ref. 26. Copyright 1999 Elsevier Science. Part B is reprinted with permission from Ref. 23. Copyright 1996 Elsevier Science.)...

Silica gel CHClj/EtOH (9/1) UV 366 nm Benzoic acid, Salicylic acid, Papaverine HCl 17... 

Silica gel Toluene / acetone (40/1) Benzoic acid. Sorbic acid. Salicylic acid 19... 

Silica gel GF254 Toluene / glacial acetic acid (80/20) UV 254 nm Benzoic acid. Salicylic acid 15... 

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