Salicylic acid disadvantages

While these agents may cause less skin irritation than benzoyl peroxide or the topical retinoids, several disadvantages exist. Sulfur preparations produce an unpleasant odor when applied to the skin, while resorcinol may cause brown scaling. And although rare, the possibility of salicylism exists with continual salicylic acid use.3,12... 

Disadvantages of these agents include the odor created by hydrogen sulfide on reaction of sulfur with the skin, the brown scale from use of resorcinol, and the possibility of salicylism from repeated and widespread use of sufficient concentrations of salicylic acid on highly permeable (inflamed and/or abraded) skin. ... 

In many cases the use of epoxy materials in so-called field conditions (for industrial, construction sites, etc.) demand an increase in the reaction velocity, which is usually achieved by adding accelerators. At present, the widely used accelerators include alkyl-substituted phenols, benzyl alcohol, carboxylic acids (in particular, salicylic acid), and others. A major disadvantage of these accelerators is their tendency to migrate from the cured epoxy matrix during the exploitation, which could lead to a change in the physical properties of the polymer. They also act as a plasticizer of epoxy-based polymers, and as a result reduce the polymer s chemical resistance. Thus, there is a need for new accelerator-modifiers that can provide faster curing of epoxy-amine compositions without negative side effects, and also improve the properties of the finished product. 

Table 5.2 Advantages and disadvantages of salicylic acid peeling ...

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