Salicylates dose-dependent effects

The two most commonly used preparations of salicylate for systemic effects are aspirin (acetylsal-icylic acid) and sodium salicylate. The dose of salicylate depends on the condition being treated. 

In dogs orally administered 50,100,250,500,800, or 1200 mg/ kg methyl salicylate for up to 10 weeks, no adverse effects were noted in animals receiving 250 mg/kg or less, but an increasing dose-dependent fatty metamorphosis of the liver was observed at higher test levels (Webb and Hansen 1963). 

Aspirin in doses used to treal rheumatoid arthritis can result in uncoupling of oxidative phosphorylation, increased oxygen consumption, depletion of hepatic glycogen, and the pyref c effect of toxic doses of salicylate. Depending on the degree of salicylate intoxication, the symptoms can vary from tinnitus to pronounced CNS and acid-base disturbance. 

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