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Salicylate-AMP ligase

Assembly of 24 (Figs. 6 and 7a) proceeds in a linear, modular fashion across the NRPS/PKS interface [62]. First, the salicylate synthase YbtS converts chorismic acid (26) to salicylic acid (27) [63, 64], which is then activated as an adenylate by the salicyl-AMP ligase, YbtE. Salicyl-AMP is tethered as a thioester to the aryl... [Pg.156]

Fig. 6 Four enzymes (one salicylate-AMP ligase YbtE/PchD, two NRPS and/or NRPS/PKS enzymes HMWPl/PchE and HMWP2/PchF, and one reductase YbtU/PchG) are required for the in vitro biosynthesis of (a) yersiniabactin (24) and (b) pyochelin (25). (c) The initial stages of 24 and 25 biosynthesis proceed via a similar mechanism from chorismic acid 26 to the salicylate-bisthiazole intermediate 33... Fig. 6 Four enzymes (one salicylate-AMP ligase YbtE/PchD, two NRPS and/or NRPS/PKS enzymes HMWPl/PchE and HMWP2/PchF, and one reductase YbtU/PchG) are required for the in vitro biosynthesis of (a) yersiniabactin (24) and (b) pyochelin (25). (c) The initial stages of 24 and 25 biosynthesis proceed via a similar mechanism from chorismic acid 26 to the salicylate-bisthiazole intermediate 33...
Thirty-one 5 -0-( M-(salicyl)sulfamoyl)adenosine inhibitors of MbtA (a salicyl AMP ligase) used with molecular dynamics simulations in a homology model to calculate linear interaction energy (R2 = 0.70 )... [Pg.254]

See other pages where Salicylate-AMP ligase is mentioned: [Pg.159]   
See also in sourсe #XX -- [ Pg.156 ]



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