Saccharomyces cerevisiae chemical structure

An X-ray structure of a thiamine dependent transketolase enzyme was determined by Schneider et al. after isolation from Saccharomyces cerevisiae in the 1990s and is shown in Fig. 10 (Sundstrom et al. 1993 Nilsson et al. 1997). The thiamine cofactor is embedded in a narrow channel in the centre of the enzyme. From the complex surrounding of the heart of this enzyme it seems to be obvious that chemical reactions at the catalytically active site in this channel proceed inevitably with high selectivities. 

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