S-Phos

Gluconeogene.si.s, Glycogen Metaboli.sm, and the Pento.s< Pho.sphate Padiway... 

First commercial production of " wet proces.s pho.sphoric acid. 

The study of the monoanions of a third class of phosphorus-containing monoesters, the phosphoramidates, has been restricted for the present to p- and o-substituted aryl phosphoramidates, and phosphoramidate and its O-methyl derivatives13-16. Two striking differences from the behavior of O- and S-phos-phate monoester monoanions are noted in the experimental criteria compiled in order to postulate mechanism (a) solvolysis in mixed organic solvents, particularly 50% v/v dioxan-water, results in a 50% decrease in the rate of hydrolysis of o- and p-substituted aryl phosphoramidate monoanions and all ionic forms of phosphoramidate and its O-methyl derivatives excepting the parent monoanion, and (b) partitioning of the aryl phosphoramidates and phos-... 

Recently, we have successfully synthesized the first series of closo-Z s( pho sphine) hy dridoo smac ar bo rane complexes, closo-3,3-(Ph3P)2-3-H-3-X-1,2-R2-... 

Certain hydrazine derivatives, when administered therapeutically (e.g.. i.soniazid). can induce a deficiency of the coenzyme (pyridoxal S-phos phute) by inactivation through the mechanism of hydrazonc formation with the aldehyde functional group. Another hydrazine derivative, hydralazine, when admini.stcied in high doses to control hypcrten.sion, can cau.se similar deficiency, conceivably through a similar mechani.sm involving hydrazone formation. 

Matsukura, M. Shinozuka, K. Zon, G. Mitsuya, H. Reitz, M. Cohen, J.S. Broder, S. Phos-phorothioate analogs of oligodeoxynucleotides Inhibitors of replication and cytopathic effects of human immunodeficiency virus. Proc. Natl. Acad. Sci. U.S.A. 1987, 84 (21), 7706-7710. 

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