S -3-Hydroxy-5-methyl-2,4-imidazolidinedione

Asymmetric Peptide Synthesis. The reagent activates amino acids through 1,3-Dicyclohexylcarbodiimide (DCC) coupling to the N-hydroximide for subsequent coupling with chiral amino acids. The asymmetric center induces preferential reaction with L-amino acids and high optical purities of L-L-dipeptides can be achieved (eq 2). Enantioselectivity is improved if the 5-methyl group is replaced by isobutyl.  

A list of General Abbreviations appears on the front Endpapers 

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