Ruthenium bipyridyl-ferrocene

Figure 23 Schematic representations of the photochromism of (a) diarylethene-biidged dinuclear bis(bipyridyl)ruthenium(II) complex, (b) diaiylethene-bridged dinuclear cyclopentadienyliron complex, and (c) diethynylethene-bridged dinuclear ferrocene complex.

Metzler-Nolte et al. successfully created organometallic PNA hybrids to provide an analytically observable tag for PNA strands, including ferrocene-PNA for electrochemical detection, (benzene)-chromiumtricarbonyl-PNA for IR detection of the carbonyl groups, and a bipyridyl-ruthenium derivative for spectroscopic and electron transfer properties. Hybridization of these strands with ssDNA has been shown to produce duplexes with stabilities only sUghtly lower ( 2°C) than an unmodified PNA-DNA system, which allows these organometallic structures to act as markers for duplex formation.Functionalized PNAs should... 

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