Rutabaga gene

Fig. 3.13 Neurofibromin signalling in learning. Gi roteirvcoupled receptors are linked to adenylyl cyclase through the a-subunit of the stimulatory G protein, Gs. Activated receptors stimulate adenylyl cyclase to synthesize cyclic AMP (cAMP), which activates the downstream effector, protein kinase A (PKA). Guo ef a/.i 3 show that the neurofibromin protein is required in this pathway for normal odour learning in Drosophila, perhaps by direct interaction with a heterotrimeric G protein or with the adenylyl cyclase encoded by the rutabaga gene (see ref 104 for further information). (This scheme is based on information published in Rg. 1 of ref. 104 and reproduced with permission of the author and Nature.)...

Lee T, Lee A, Luo L (1999) Development of the Drosophila mushroom bodies sequential generation of three distinct types of neurons from a neuroblast. Development 126 4065-4076 Levin LR, Han PL, Hwang PM, Feinstein PG, Davis RL, Reed RR (1992) The Drosophila learning and memory gene rutabaga encodes a Ca2Vcalmodulin-responsive adenylyl cyclase. Cell 68 479-489 Li J, Ashley J, Budnik V, Bhat MA (2007) Crucial role of Drosophila neurexin in proper active zone apposition to postsynaptic densities, synaptic growth, and synaptic transmission. Neuron 55 741-755... 

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