Ruptured berry aneurysm

Infarction of the brain is involved in stroke, ruptured berry aneurysm, traumatic brain... 

A woman taking propranolol 40 mg four times daily for hypertension was given one drop of a 10% phenylephrine hydrochloride solution in each eye during an ophthalmic examination. About 45 minutes later she complained of a sudden and sharp bi-temporal pain and shortly afterwards became unconscious. She later died of an intracerebral haemorrhage due to the rupture of a berry aneurysm. She had received a similar dose of phenylephrine on a previous occasion in the absence of propranolol without any problems. ... 

Crompton, M. R., 1964 The pathogenesis of cerebral infarction following the rupture of cerebral berry aneurysms. Brain 87, 491-510. 

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