RSM and Experimental design

With the use of such an empirical model, the crushing strength can be optimized with respect to the relative amounts of excipients. The empirical model above can be represented as a surface in the 3-D space, where the axis are x, X2 and CR. Hence, this methodology is called response surface methodology. Good textbooks have appeared in the area of RSM [14,16]. 

In order to optimize the information content of experiments, it is wise to plan the experiments ahead in a well defined manner. Formal ways to plan 

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