RPAR

EPA, RPAR Candidates Chemical Review Schedule List. 

It should be noted that hazard or risk is a function of exposure as well as of toxicity. Thus, an important aspect of this continued debate on 2,1+,5-T is the need for representative data on real exposure in humans, not only for applicators of the herbicide but for the populace at large. EPA s RPAR Position Document 1 (l) included estimates of exposure to 2,1i,5-T based on direct measurements of external contamination by other pesticides applied with equipment similar to that used for 2,li,5-T. However, in most cases, application conditions were quite different from those used for 2,1+,5-T. 

Leng, M. L. Realistic Evaluation of Human Exposure from Application of 2,4,5-T Sprays. Unpublished report of The Dow Chemical Company submitted to EPA in response to 2,4,5-T RPAR, August 4, 1978 ( 16b, Volume II, Appendix V). 

Workers, August 30 to October 3, 1978. Project Completion Report to National Forest Products Association, December 22, 1978, submitted to EPA in response to 2, +,5-T RPAR,... 

Studies on the scaleless chicken are underway examining its suitability as a model for assessing toxicity of organophosphates. The first compound selected for field trials was the defoliant DEF (S,S,S-tributylphosphorotrithioate) used during the harvesting of cotton in California and Arizona in the fall (October-November) when air movements are frequently restricted by inversions. DEF has been the subject of sufficient complaints to place it on the pre-RPAR list, although there are no reports of acute or delayed neurotoxicity in humans when it and related chemicals are used according to recommendations. It both inhibits cholinesterases and causes delayed neurotoxicity in hens (3,6). 

Successor to DBCP was the equally suspect ethylene dibromide (EDB), (ref. 26) widely used as a fumigant on fruits and vegetables. Based on the National Cancer Institute s finding of carcinogenicity of EDB the Environmental Defense Fund petitioned for cancellation of EDB registration. The EPA responded with an RPAR notice in December 1977. Three years later (Dec. 1980) the agency announced its preliminary decision to cancel EDB registration for use on stored... 

Rhodopseudomonas palustris is an anoxigenic phototrophic soil bacterium. Rhodopseudomonas palustris has lux and luxR homologues, rpal and rpaR,iS0 and the expression of rpal is activated by adding -coumarate into the growth medium.351 It was found that R. palustris produced >-coumaroyl-HSF (Figure 42) by Rpal using... 

CHAPTER 1 The Basics of Reaction Kinptirc fnr Chsmin l Rpar.tion Enninefirino... 

CHAPJTER 2 Rate Hnnstants nf FiAmpntary Rpar.tions... 

A Rwork,Lrw,lwork,Liw,Rpar,lpar,ldid,LUI IREP,LUNERR,lrange,... 

Nspar is the number of parameters (independent of t) whose sensitivity functions are to be calculated. These parameters must be stored in the array Rpar, in locations specified via the array Ipar as described at the end of this section. 

Rpar is a double precision work array, and Ipar is an integer work array. These are provided so that DDAPLUS can pass special information to the user-provided subroutines. The parameters whose sensitivity coefficients are desired must be stored in the Rpar array in the locations specified by the elements l,.Nspar of the array Ipar. For example, the input Ipar(2)=3 would indicate that the second sensitivity parameter was stored in Rpar(3). The location Ipar(O) is reserved for a user-defined constant, such as the address (later in Ipar) of a list of pointers to other information. The location Rpar(O) may be used to store values of a user-defined continuation parameter. 

Subroutine fsub (t, Nstvar, U, fval, Rpar, Ipar, Irange, Imodel, Ires )... 

Double precision t, U( ), fval( ), Rpar(0 ), Integer Nstvar, lpar(0 ), Irange, Ires,. 

Smale BC. 1977. Coal-tar creosote and coal-tar pesticides as candidates for RPAR. Unpublished EPA... 

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