Role of the basic region in DNA binding

A distinctive feature of many HMG-box proteins is a basic extension either C- or N-terminal to the HMG box. In the case of both the sequence-specific LEF-1 HMG box [25] and the non-sequence-specific Nhp6ap and HMG-D boxes 

Proposed structure of a complex of the HMGB1 A-domain with a four-way junction 

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