Role of Lipophilicity in Drug Clearance

For hydrophilic drugs (log D7 4 below 0) renal clearance is the predominant mechanism. For drugs with log D74 values above 0, renal clearance decreases with lipophilicity. In contrast to renal clearance, metabolic clearance increases with in- 

Propranolol is considerably more potent (albeit less selective) than atenolol. Thus despite a much higher clearance than atenolol, both agents have a daily clinical dose size of around 25-100 mg. 

2 Gardner IB, Walker DK, Lennard MS, Smith DA, Tucker GT, Xenobiotka. 1995, 25,185-197. 

3 Yabuki M, Mine T, Iba K, Nakatsuka 1, Yoshitake A, Drug Metab. Dispos. 1994, 22, 294-297. 

4 Smith DA, In Computer-Assisted Lead Finding and Optimisation (Eds Van de 

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