Role of Instrumented Filling Machines and Simulation

SCALINC-UP WITHIN THE SAME DESIGN AND OPERATING PRINCIPLE 

Regulatory Meaning of Same Design and Operating Principle 

Model Maximum rated output (capsules/hr) Maximum cycle speed (cycles/min) Powder bowl diameter (in.) Number of tamping pins at each station 

The MG-2 series of dosator machines also exhibit similar plug forming parameters across machines with different production capacities. For example, the 16 station (up to 48,000 capsules per hour) and 64 station machines (actually a double 32 station machine up to 200,000 capsules per hour) operate at the same RPM, have the same spacing between dosators, and have similar dosator penetration and withdrawal speeds, plug compression dwell times and plug ejection speeds (McKee, 2005 ). Unlike the powder bed 

The MG-2 Futura series of machines can be fitted with different numbers of dosators to give outputs ranging from 6000 to 96,000 capsules per hour. Because turret and annular powder bed dimensions would remain the same, few problems should be expected when scaling-up within this range on this machine. However, it is important to recognize that since the distance between dosators will increase when fewer than the full complement 

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