Role of Erythrocytes and White Cells on Platelet-Biomaterial Interactions

6 Role of erythrocytes and white cells on platelet-biomaterial interactions 

Red cell-surface interactions may play a major role in the dynamics of protein and platelet behaviour at the interface. The effect of red cells on platelet sticking has been noted widely, causing an augmentation of the rate of adhesion, probably by a combination of physical and biochemical mechanisms (40). Hellem et al (45) have observed that red cell ghosts restore retension of platelets in colunrn almost as 

The platelet adhesion and spreading was higher with bare polymer (Fig 5A), which had substantially reduced due to SPE (Fig 5B) treatments. The adhesion and spreading of platelets (finm PRP, 2 hours) on silated silicone wafer was similarly i bited by pretreatment with sulphonated polyelectrolytes (Fig 6). Regardless of treatment with SPE, all platelets adherent to polycarbonate and silicone wafer were pseudopodial (Fig 5 6). 

Scanning electron micrographs of adhered platelets to (A) Polycarbonate and (B) Polyelectrolyte coated polycarbonate, on exposure to PRP for I hour. 

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