Rohmer

Slone CS, Weinberger DA, Mirkin CA (1999) Prog Inorg Chem 48 233 Braunstein P, Naud F, Dedieu A, Rohmer M-M, DeCian A, Rettig SJ (2001) Organometallics 20 2966... 

Gloaguen F, Lawrence JD, Rauchfuss TB, Benard M, Rohmer M-M (2002) Inorg Chem... 

Rohmer, M., The discovery of a mevalonate-independent pathway for isoprenoid biosynthesis in bacteria, algae and higher plants, Nat. Prod. Rep., 16, 565, 1999. 

Lichtenthaler HK, Schwender J, Disch A, Rohmer M (1997) FEES Lett 400 271... 

Dolbecq A, Guirauden A, Fourmigue M, Boubekeur K, Batail P, Rohmer MM, Be-nard M, Coulon C, Salle M, Blanchard P (1999) J Chem Soc Dalton Trans, p 1241... 

Portal page to the Preface (by Sax Rohmer) and 6 sections. Transcribed by Mark House. 1925 edition. 

Rohmer, M., P. Bouvier, and G. Ourisson. 1979. Molecular evolution of biomembranes structural equivalents and phylogenetic precursors of sterols. Proc. Natl. Acad. Sci. USA 76 847-851. 

The hypothesis that polar carotenoids regulate membrane fluidity of prokaryotes (performing a function similar to cholesterol in eukaryotes) was postulated by Rohmer et al. (1979). Thus, the effects of polar carotenoids on membrane properties should be similar in many ways to the effects caused by cholesterol. These similarities were demonstrated using different EPR spin-labeling approaches in which the effects of dipolar, terminally dihydroxylated carotenoids such as lutein,... 

Rohmer, M., Seemann, M., Horbach, S. et al. (1996) Glyceraldehyde 3-phosphate and pyruvate as precursors of isoprenic units in an alternative non-mevalonate pathway for terpenoid biosynthesis. Journal of the American... 

Espinosa, E., C. Lecomte, N. E. Ghermani, J. Devemy, M. M. Rohmer, M. Benard, and E. Molins. 1996. Hydrogen Bonds First Quantitative Agreement between Electrostatic Potential Calculations from Experimental X-(X+N) and Theoretical Ab Initio SCF Models. J. Am Chem. Soc. 118, 2501. 

Disch, A., Schwender, J., Muller, C., Lichtenthaler, H.K., and Rohmer, M., Distribution of the mevalonate and glyceraldehyde phosphate/pyruvate pathways for isoprenoid biosynthesis in unicellular algae and the cyanobacterium Synechocystis PCC 6714, Biochem.., 333, 381, 1998. 

RODRIGUEZ-CONCEPTION, M., CAMPOS, N MARIA LOIS, L., MALDONADO, C., HOEFFLER, J.F., GROSDEMANGE-BILLIARD, C., ROHMER, M., BORONAT, A., Genetic evidence of branching in the isoprenoid pathway for the production of isopentenyl diphosphate and dimethylallyl diphosphate in Escherichia coli, FEBS Lett., 2000,473, 328-332. 

ROHMER, M., KNANI, M., SIMONIN, P., SUTTER, B., SAHM, H., Isoprenoid biosynthesis in bacteria a novel pathway for the early steps leading to isopentenyl diphosphate, Biochem. J., 1993,295, 517-524. 

SCHWENDER, J., SEEMANN, M LICHTENTHALER, H.K., ROHMER, M., Biosynthesis of isoprenoids (carotenoids, sterols, prenyl side-chains of chlorophylls and plastoquinone) via a novel pyruvate/glyceraldehyde 3-phosphate non-mevalonate pathway in the green alga Scenedesmus obliquus, Biochem. J., 1996, 316, 73-80. 

DUVOLD, T., BRAVO, J.-M., PALE-GROSDEMANGE, C., ROHMER, M., Biosynthesis of 2-C-methyl-D-erythritol, a putative C5 intermediate in the mevalonate independent pathway for isoprenoid biosynthesis, Tetrahedron Lett., 1997, 38, 4769-4772. 

The CPPase substrate DMAPP (15) is formed from isopentenyl pyrophosphate (IPP) (14) via the IPP isomerase reaction. It had been assumed that IPP was generated only via mevalonic acid (12) (Fig. 2), but Rohmer discovered another route, 2-C-methyl-D-erythritol 4-phosphate (13) (MEP) pathway (Fig. 2) [22, 23]. A key step in the MEP pathway is the reaction catalyzed by 1-deoxy-D-xylulose 5-phosphate synthase (DXS), which combines hydroxyethyl thiamine pyrophosphate (hydroxyethyl TPP) generated from pyruvic acid (17) and TPP with glyceral-dehyde 3-phosphate (18) to yield 1-deoxy-D-xylulose 5-phosphate (19) containing five carbons. The mevalonate pathway operates in the cytosol of plants and animals, whereas the MEP pathway is present in the plastid of plants or in eubacteria [24-27]. 

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