RNA polymerases in eukaryotic cells

With respect to the general mechanism of RNA chain growth, are there any differences among the various types of RNA polymerase in eukaryotic cells ... 

General transcription factors belong to a group of proteins which assemble at the TATA box or a similar region in the promoter.They are required for the initiation of transcription by the DNA-dependent RNA polymerase in eukaryotic cells. 

Rifampicin (Fig. 10.70) is a semisynthetic rifamycin made from rifamycin B—an antibiotic isolated from Streptomyces mediterranei. It inhibits Gram-positive bacteria and works by binding non-covalently to RNA polymerase and inhibiting RNA synthesis. The DNA-dependent RNA polymerases in eukaryotic cells are unaffected, since the drug binds to a peptide chain not present in the mammalian RNA polymerase. It is therefore highly selective. 

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See also in sourсe #XX -- [ ]

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