RNA polymerase II transcription

Dickinson, L.A., J.W. Trauger, E.E. Baird, P. Ghazal, P. B. Dervan, and J.M. Gottesfeld. Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides. Biochemistry 1999, 38, 10801-10807. 

TAF 250 TBP-Associated Factor II 250. Another direct connection between acetylation and transcriptional activation was demonstrated with the discovery that one of the TAFII (TATA-binding protein [TBP]-associated factor) subunits of the general transcription factor TFIID is itself a HAT. TFIID is one of the general factors required for the assembly of the RNA polymerase II transcription preinitiation... 

Nikolov, D.B. and Burley, S.K. RNA polymerase II transcription initiation a structural view (1997) Proc Natl Acad Sci U S A 94,15-22. 

Source Adapted from Reece, R. Platt, A. (1997) Signaling activation and repression of RNA polymerase II transcription in yeast. Bioessays 19, 1001-1010. 

Boube, M., Joulia, L., Cribbs, D.L., Bourbon, H.M. (2002) Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man. Cell 110, 143-151. 

MV Davies, J Pelletier, K Meerovitch, N Sonenberg, RJ Kaufman. The effect of poliovirus proteinase 2Apro expression on cellular metabolism. Inhibition of DNA replication, RNA polymerase II transcription, and translation. J Biol Chem 266 14714-14720, 1991. 

Dickinson LA, et al. Inhihition of RNA polymerase II transcription in human cells hy synthetic DNA-hinding hgands. Proc. Natl. Acad. Sci. U.S.A. 1998 95 12890-12895. 

S. Buratowski. 2000. Snapshots of RNA polymerase II transcription initiation Curr. Opin. Cell Biol. 12 320-325. (PubMed)... 

Cheng HL, He XY, Moore C. The essential WD repeat protein Swd2 has dual fimetions in RNA polymerase II transcription termination and lysine 4 methylation of histone H3. Mol Cell Biol 2004 24(7) 2932-43. 

Chao SH, Price DH. 2001. Flavopiri-dol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo. J. Biol. Chem. 276 31795-99... 

TATA signal — TATA box Goldberg-Hogness box a conserved AT-rich septamer found about 25 bp before the start point of each eukaryotic RNA polymerase II transcript unit which may be involved in positioning the enzyme for correct initiation consensus=TATA(A or T)A(A or T) [3536]... 

TATA box is the first step in the assembly of the RNA polymerase II transcription complex. The frequency of transcription initiation is often affected by binding certain transcription factors to upstream elements such as the CAAT box and the GC box. The activity of many promoters is affected by enhancers, regulatory sequences that may occur thousands of base pairs upstream or downstream of the gene they affect. (In yeast these sequences are called upstream activator sequences, or UAS.) The effects of enhancers can be complex. For example, a single gene may be controlled by the combined activities of several enhancers. Hormone response elements (Section 16.4) often act as enhancers. 

D., and Hanawalt, P.C. (1997) Nucleotide sequence context effect of a cyclobutane pyrimidine dimer upon RNA polymerase II transcription. 

See also Transcription, Translation, RNA Polymerases, Background on Transcription, RNA Polymerase II Transcription, Eukaryotic Transcription,... 

See also RNA Polymerase II Transcription, Termination of Eukaryotic Transcription, Chromatin Remodeling... 

See also Eukaryotic Transcription, Eukaryotic Transcriptional Initiation/Elongation, RNA Polymerase II Transcription, Processing of mRNA... 

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