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Ring Size and Structure

It is important to note that not only is ring size important, but also ring structure. For example, some of the most stable chelates are those of the acetylacetonate (acac) ion  [Pg.454]

When two such ions coordinate to a +2 metal ion, a neutral complex results and when three acac ions coordinate to a +3 metal ion, the complex is also neutral. The rings formed with the metal ion are planar, with C-C and C-0 bond distances of 138 pm and 128 pm, respectively. These bond distances are somewhat shorter than the values of 154 and 143 pm expected for single bonds of the C-C and C-0 types. [Pg.454]

The planar chelate rings and the short bonds indicate that resonance structures can be drawn showing some -electron delocalization. For simplicity, only one of the chelate rings in a complex such as M(acac)3 is shown in the resonance structures here to display the bonding  [Pg.455]

These structures illustrate that the rings possess some degree of aromaticity. Because acac complexes are usually uncharged and nonpolar, they are surprisingly soluble in organic solvents. The extreme stability of complexes of this type permits reactions to be carried out on the ring without disruption of the complex. One such reaction is bromination, which is illustrated in the equation  [Pg.455]

Several reactions of this type that are typically considered to be electrophilic substitutions occur on the chelate ring. The following equation can be considered as a general reaction of this type, [Pg.455]


The influence of ring size and structure over the melting points of thiamacrocycles has been reflected by the authors of CHEC-II(1996) and is not discussed herein. The melting points of the newly synthesized ring systems are listed in Table 2 as far as they are available from the original references. [Pg.756]

Numbers of Macrolides Classified by Their Ring Sizes and Structural Characteristics ... [Pg.3]

The local level, which reflects the chemical structure of a single chelate unit in the chain molecule (the nature of the metal-complexing agent and functional groups, the ring size and structure, etc.). [Pg.85]

Various cychc esters have been subjected to hpase-catalyzed ring-opening polymerization (ROP), notably of four- to 17-membered nonsubstituted lactones. Initially, it was shown that medium-sized lactones, 5-valerolactone (5-VL, six-membered) and e-CL (seven-membered), were each polymerized via the action of a lipase from Candida cylindracea (hpase CC), hpases BC and PF, and a porcine pancreatic hpase (PPL) [83,84]. Later, a variety of cychc esters with different ring sizes and structures were also polymerized via a hpase-mediated catalysis. [Pg.689]

In recent years the effects of crown ethers on enzyme reactions in organic solvents have been investigated. Depending on their ring size and structure, crown ethers can form complexes with metal ions, ammonium groups, guanidinium groups, and water, species that are all common in enzymatic reactions. [Pg.81]

Table 2.6. Structural features (carbon hybridisation, electronegativity, ring size) and typical one-bond CH coupling constants Jch (Hz) ... Table 2.6. Structural features (carbon hybridisation, electronegativity, ring size) and typical one-bond CH coupling constants Jch (Hz) ...
The racemization of medium-ring trans-cycloalkenes depends upon ring size and substitution, as indicated by the data below. Discuss these relative reactivities in terms of the structures of the cycloalkenes and the mechanism of racemization. [Pg.116]

Other less general routes to the medium-size ring sulfoxide and sulfone systems do exist, but each one is specific to a particular ring size and to the specifically desired structural features of the target molecule. Equations 131 and 132 are two examples353,354 of such syntheses. [Pg.472]

Monosaccharides can differ in their formulas, their ring sizes, and the spatial orientations of their hydroxyl groups. To analyze the differences between two monosaccharides, begin with structural drawings of the molecules, oriented so the ether linkages are in comparable positions. Then examine the stmctures to locate differences in constituents and bond orientations. [Pg.922]

Electrophilic cyclizations are useful for closure of a variety of oxygen-, nitrogen-, and sulfur-containing rings. The product structure depends on the ring size and the exo-endo selectivity. The most common cases are formation of five- and six-membered... [Pg.311]

Several of the copper and rhodium catalysts were compared in an intramolecular cyclopropanation.210 For the reaction leading to formation of a 10-membered ring, shown below, the copper catalysts gave higher enantioselectivity, but there were many subtleties, depending on ring size and other structural features in related systems. [Pg.932]

Heterocyclic scaffolds form the cores of many pharmaceutically relevant substances. Not surprisingly, therefore, many publications in the area of microwave-assisted organic synthesis, both from academia and industry, deal with the preparation of heterocycles [5], In this final section of this chapter, the description of heterocycle synthesis is structured according to ring-size and the number of heteroatoms in the ring. [Pg.222]

This study also suggests that molecular size and structure play a role in this interaction. The binding behaviors of dextrin oligomers for four different pharmaceuticals (ibuprofen, ketoprofen, furosemide, and warfarin) were observed under the same experimental conditions. Ibuprofen and ketoprofen, two compounds that are similar in chemical structure and pharmaceutical use, showed obvious differences in interaction patterns (Fig. 13A and B). Ketoprofen, having an extra aromatic ring, required an octa-saccharide (DP = 8) for binding, whereas ibuprofen required a heptasac-... [Pg.305]

Pyridine-2,6-dicarbaldehyde and 2,6-diacetylpyridine have been widely used in the template synthesis of imine chelates ranging in complexity from linear tridentates, such as (17),38 39 to macrocyclic structures with a range of ring sizes, such as (18).40-42 The in situ formation of macrocyclic ligands of this type depends upon the ring size and the strength of complexation of the triamine by the metal ion at the pH of the reaction. Related complexes with an additional donor atom attached to R2 have been synthesized also.43 44... [Pg.159]


See other pages where Ring Size and Structure is mentioned: [Pg.454]    [Pg.165]    [Pg.194]    [Pg.454]    [Pg.165]    [Pg.194]    [Pg.177]    [Pg.227]    [Pg.471]    [Pg.471]    [Pg.168]    [Pg.609]    [Pg.7]    [Pg.187]    [Pg.61]    [Pg.717]    [Pg.26]    [Pg.147]    [Pg.65]    [Pg.139]    [Pg.119]    [Pg.155]    [Pg.120]    [Pg.1230]    [Pg.20]    [Pg.236]    [Pg.146]    [Pg.680]    [Pg.204]    [Pg.908]    [Pg.115]    [Pg.253]    [Pg.252]    [Pg.351]    [Pg.17]   


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