Ring-opening metathesis copolymerization ROMP

Barrett and co-workers adapted ring-opening metathesis polymerization (ROMP) to prepare the ROMPgel TosMlC reagent 1621 (Scheme 1.414, p. 364). Thus copolymerization of the norbornene-derived formamide 1620 with norbor-nene in the presence of Grubbs s catalyst" gave 1621 in quantitative yield after dehydration. Aromatic aldehydes react with 1621 in the presence of a strong... 

In Chapter 9, the authors have described the ring opening metathesis polymerization procedure that has potential application in cancer therapy. The synthesis and complete characterization of both norbomene derived doxorubicin (mono 1) and polyethylene glycol (mono 2) monomers have been clearly described. Secondly their copolymerization by ring-opening metathesis polymerization (ROMP) to get the block copolymer has been vividly elaborated. Similarly the NDB monomer as well as its homopolymer (NDBH) synthesis and complete characterization have been thoroughly discussed. 

There are three different mechanisms by which the cyclic olefin norbornene can be polymerized to reasonably high molecular weights ring-opening metathesis polymerization (or ROMP), vinyl addition copolymerization with acyclic olefins such as ethylene, and vinyl addition homopolymerization (see Fig. 4.2). Carbocationic and free-radical initiated polymerizations are ignored since they yield only low molecular weight oligomers [8]. 

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