Rimonabant Rifampicin

Rimonabant is partly metabolised by the cytochrome P450 isoenzyme C YP3A4. Ketoconazole, a potent CYKIA4 inhibitor, doubles the AUC of rimonabant. The manufacturers therefore expect that other potent CYP3A4 inhibitors (they name clarithromycin, itraconazole, nefazo-done, ritonavir, and teUthromycin) will also raise rimonabant levels, and they therefore advise caution on concurrent use. They similarly suggest that potent CYP3A4 inducers (such as carbamazepine, phenobarbital, phenytoin, rifampicin (rifampin) and St John s wort) may lower rimonabant levels. If concurrent use is necessary monitor to ensure that rimonabant remains effective. See Table 1.4 , (p.6), for a list of clinically relevant CYE 3A4 inducers and inhibitors. 

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See also in sourсe #XX -- [ ]

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