Rigid analogs

Another series of rigid analogs that have been examined to some degree are the aminotetralins with the general formula of Structure 17. If, as might be... 

Phenylalanine derivatives, substituted either with 3,4,5-trimethoxy or 2,5-dimethoxy-4-methyl substituents did not show activity (46). Although these would yield potentially active phenethylamines if decarboxylated in vivo, neither is likely to be a substrate for decarboxylases in the CNS (62). Several additional side chain alkylated compounds are discussed in the next section as rigid analogs. 

NMR spectroscopy is useful for determining the conformations of biological molecules such as neurotransmitters. For example, information about the con formations of acetylcholine has been used to design rigid analogs that are used as drugs to treat Alzheimer s disease. 

Rigid analogs (33), (34), and (35) of phencyclidine (36) possess a rigid carbocyclicstnic-... 

Murphy, P V, Hubbard, R E, ManaUack, D T, Wills, R E, Montana, J G, Taylor, R J K, The design, synthesis, and evaluation of novel conformationaUy rigid analogs of sialyl Lewis , Bioorg. Med. Chem. Lett, 41, 2421-2439, 1998. 

Qiu, J. and Silverman, R. B. (2000) Anew class of conformationally rigid analogs of 4-amino-... 

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