Rieke synthetic route

The synthesis of spiro y-lactones has been extended to the synthesis of spiro -lactones. This one-pot transformation of 1,3-dienes reacted with epoxides, mediated by Rieke magnesium to spiro -lactones in good isolated yields, was recently reported [15]. Much work has been done to elucidate novel synthetic routes for these types of molecules [16]. In particular, -substituted 5-lactones have recently attracted considerable attention, mainly because molecules of this class include many natural products that exhibit substantial biological activity [17]. However, most methods for the synthesis of these molecules require... 

We have demonstrated a practical synthetic route for the preparation of 2-pyridyl and 3-pyridyl derivatives. It has been accomplished by utilizing a simple coupling reaction of readily available 2-pyridylzinc bromides and 3-pyridylzinc bromides, which were prepared via the direct insertion of active zinc to the corresponding bromopyridines, or they can be purchased (Rieke... 

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