Ribonucleotide reductase substrate analogues

In addition to the above considerations, one approach to design nucleoside analogues that exert a broad spectrum of activity toward both leukemic and solid tumors has been the construction of analogues that (i) are not substrates for cytidine deaminase, (ii) are converted into the corresponding 5 -polyphosphates by certain kinases, which inhibit ribonucleotide reductase and/or DNA polymerases, and can also be incorporated into a DNA molecule, (iii) have a chemically reactive functionality at the 2 -P position of 2 -deoxycytidine, which is chemically stable at the nucleoside level but would be expected to be reactive after incorporation into a DNA molecule to cleave phosphodiester linkages and/or to produce... 

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