Ribonucleases deoxy, amino acids

Syntheses have been reported for a number of glycopeptide derivatives containing the JV -(2-acetamido-2-deoxy-/J-D-glucopyranosyl) hydrogen L-asparagin-ate linkage and having the amino-acid sequences 32-34, 33-35, 33-37, and 33-38 of bovine ribonuclease. ... 

During digestive processes, nucleoprotein is split into nucleic acids and protein, the latter then being broken down into amino acids. The nucleic acids are attacked by ribonuclease and deoxyribonuclease enzymes to form nucleotides, which are further hydrolysed by nucleotidases to form nucleosides and phosphates. In the intestines these nucleosides are split by nucleosidases into ribose, deoxy-ribose, purine and pyrimidine bases, which later undergo oxidation and decomposition to ammonia, carbon dioxide and water, to be finally expelled as urea. Nucleotide hydrolysis products are conveniently identified and isolated by chromatographic methods (Chapter 14.2). 

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