Rhodium-Catalysed Mizoroki-Heck-Type Reactions

6 Rhodium-Catalysed Mizoroki-Heck-Type Reactions 

In a related intramolecular rhodium-catalysed Mizoroki-Heck-type reaction of an alkene with an aryl iodide, Wilkinson s catalyst (84) gave significant amounts of side-products due to isomerization of the resulting double bond. In contrast to the corresponding palladium-catalysed transformation, the presence of Et4NCl had no beneficial influence either on the reactivity or on the selectivity [57]. 

As an alternative to the use of aryl halides as electrophiles, Miura and coworkers [59] employed aroyl chlorides in rhodium-catalysed decarbonylative Mizoroki-Heck-type 

The potential of iridium-catalysed arylations of alkenes with organic halides as electrophiles has thus far not been explored further. However, a notable iridium-catalysed arylation of alkenes with organosilicon reagents was disclosed recently [15]. 

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Scheme 10.32 Rhodium-catalysed Mizoroki-Heck-type reaction with arylsulfonyl chloride 91.

Scheme 10.30 Rhodium-catalysed intermolecular Mizoroki-Heck-type reaction with Wilkinson s catalyst (84).

Scheme 1031 Rhodium-catalysed decarbonylative Mizoroki-Heck-type reaction.

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