Rheedia gardneriana

Cechinel Eilho, V. et al., I3-naringenin-II8-4 -OMe-eriodyctol a new potential analgesic agent isolated from Rheedia gardneriana leaves, Z. Naturforsch., 55, 820, 2000. 

Rodrigues, C. A. Oliveira, A. E. Willain, F. R. Cechinel-Filho, V. Guimaraes, C. L. Yimes, R. A. Delle Monache, F., Separation of biflavonoids from Rheedia gardneriana using chitin-Fe complex as stationary phase, Die Pharmazie, 2000, 55, 699-700. 

Rheedia gardneriana, a plant used in traditional medicine in Brazil, contains some biflavonoids that exhibit antinocicetive effects. 13-narin-II8-4 -Ome-eridictyol is a biflavonoid which contains a methoxyl group in position 4 of ring-II. It has revealed potent dose-dependent antinociceptive action during writhing and formalin tests. Results have shown that the effect of this biflavonoid against the second phase of the formalin test was not associated with inhibition of paw oedema. Further studies are necessary to elucidate the mechanism of this compound [94]. 

Braz Filho R, DeMagalhaes GC, Gottlieb OR 1970 Xanthones of Rheedia gardneriana. Phytochemistry 9 673... 

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