Triage reverse

Fast LC-MS methods have been used to assess library quantity and purity, as well as to triage purification of compounds. Zeng et al. [51] developed one of the first fully automated analytical/preparative LC-MS systems for the characterization and purification of compound libraries derived by parallel synthesis. The system incorporated fast, reverse-phase LC/ESI-MS analysis (5-10 minutes). Post-data-acquisition purity assessment of compound ti-braries was performed automatically with software control. Compounds that were below a threshold level of purity were automatically purified with HPLC. The real-time purity assessment eliminated the need for postpurification analysis or pooling of fractions collected. 

In a casualty with mild-to-moderate intoxication from exposure to nerve agent vapor, administering the contents of MARK I kits can rapidly and completely reverse the nerve agent effects. Further triage decisions and medical care should focus on the conventional wound. 

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