Reverse molecular motifs

Applying short ssDNA strands that selectively interact with a specific part of a molecular device is another method to make the device move. A robust rotary device was developed based on multiple crossover motifs [91]. The motivity of the device was the reversible binding of DNA strands. The central axis consists of a couple of ssDNA sections. The conformation of the two ssDNA strands can readily be switched between a PX conformation and its topoisomer conformation. The ssDNA strand replacement can cause the interconversion between the two conformations, and results in an 180° rotation of the end of one strand. This work showed that a rotary nanomechanical device is capable of being cycled by the addition of strands that direct its structure (Fig. 12a). As an application of the DNA nanodevice, a unique DNA nanomechanical device that enables the positional synthesis of products whose sequences are determined by the state of the device has been... 

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