Retrosynthetic catalysis

Mechanisms and catalysis chl3 Removal of functional groups Retrosynthetic analysis ch30... 

The sulfide-catalyzed enantioselective epoxidation reaction is the most extensively studied transformation in ylide catalysis, and two ylide generation methods (aUcylation/deprotonation and carbene transfer) have been developed. Compared with conventional methods for epoxidation via oxygen transfer to the carbon-carbon double bond, such as the Sharpless epoxidation, Jacobsen-Katsuki epoxidation, and Shi epoxidation, the yhde approach can be regarded as an alkyUdene transfer reaction to carbonyl groups (C=0), providing a different retrosynthetic analysis for the construction of epoxides. In particular, in the synthesis of vinyl epoxides, the ylide route has priority over conventional oxidation methods, since the issue of regjoselectivity in the epoxidation of dienes will not be present [32]. 

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