Retrometabolic drug design

N. Bodor, P. Buchwald, and M.-J. Huang, The role of computational techniques in retrometabolic drug design strategies, Computational Molecular Biology (J. Leszczynski, ed.), Elsevier, Amsterdam, 1999, p. 569. 

N. Bodor, Drug targeting and retrometabolic drug design approaches, Adv. Drug Delivery Rev. 74 157 (1994). 

Figure 15.1. The retrometabolic drug design loop, includingchemical delivery system (CDS) design and soft drug (SD) design. A schematic representation of possible metabolic pathways for drugs in general is also included (see text for details).

The present chapter attempted to systematize and summarize several novel metabolisn-based drug design approaches collected under the umbrella of retrometabolic drug design... 

THE ROLE OF COMPUTATIONAL TECHNIQUES IN RETROMETABOLIC DRUG DESIGN STRATEGIES... 

Two different predictive methods to estimate log P iv, were developed within our own Center. Considering the diversity of retrometabolic drug design approaches, such versatility is needed since at different ends of the retrometabolic loop one has to deal with vei7 different molecular structures. 

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