Principles of retrometabolic drug design

By combining structure-activity, -nical considerations, they allow the design relationships (SMR) and physicoo i of safe, localized compounds. 

Since all these retrometabolic approaches are considerably flexible, for certain lead compounds a large number of possible drug candidates can be envisaged. Finding the best drug candidate among them may prove tedious and difficult. Fortunately, computational techniques allow the estimation of various molecular properties, and more quantitative design is possible. 

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