Retro-aldol Reactions in Human Therapy Prodrug Activation by Aldolase Antibody

Retro-aldol Reactions in Human Therapy Prodrug Activation by Aldolase Antibody 

An important application of aldolase antibodies is prodrug activation in chemotherapeutic strategies. Activation of a prodrug into an active drug at the tumor site enables selective destruction of those tumor cells. This type of site-specific targeting is known as antibody-directed enzyme prodrug therapy (ADEPT) [25]. The ADEPT complex serves two functions. The antibody portion of the complex enables delivery of the drug directly to the tu- 

Syntheses of brevicomins using aldolase antibody-catalyzed reactions. 

Synthesis of 1-deoxy-L-xylulose using aldolase antibody-catalyzed reaction. 

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