Retinoids limb regeneration

As in the case of chicks, various methods have been used to treat amphibians with retinoids and for two experimental purposes first, to study early development, and second, to study limb development and regeneration. Obviously, these two types of experiments involve treatment at widely differing stages, and a large number of different species of amphibians have been used for limb regeneration studies. 

Pecorino, L. T, Lo, D. C., and Brockes, J. P. (1994) Isoform-specific induction of a retinoid-responsive antigen after bioUstic transfection of chimaeric retinoic acid/ thyroid hormone receptors into a regenerating limb. Development 120,325-333. 

Keeble, S. and Maden, M. (1989) The relationship among retinoid stracture, affinity for retinoic acid-binding protein and ability to respecify pattern in the regenerating axolotl limb. Dev. Biol. 132,26-34. 

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