Retinoids and Rexinoids in the Clinic

Compound (drug name) Indication Pharmacology Clinical status Company name [Pg.393]

ATRA (1) (Tretinoin) acne, photodamage, acute promyelocytic leukemia (AML) RAR agonist, protein synthesis antagonist, microbial collagenase inhibitor launched AP Pharma, Johnson Johnson, HofF-mann-La Roche, Myland Labs [Pg.393]

9-CRA (2) (alitretinoin) psoriasis, Kaposi s sarcoma, AML RAR and RXR agonist, apoptosis agonist launched Ligand [Pg.393]

13-CRA (3) (isotretinoin) acne RAR agonist, protein synthesis antagonist, microbial launched Hoffmann-La Roche [Pg.393]

Etretinate (4a), acitretin (4b) breast cancer, nonsmall cell lung cancer, Kaposi s sarcoma, T cell lymphoma RXR agonist launched Hoffmann-La Roche [Pg.393]

Big Chemical Encyclopedia