Retinoic acid bioassay systems

In the MDCK cells, treatment with iV-(4-hydroxyphenyl)retinamide did not inhibit arachidonic acid release, suggesting that the retinoid was possibly acting as a cyclooxygenase inhibitor. Whether this enzyme inhibition is related to the retinoid character of the molecule or to a particular spatial configuration of the phenolic end group in the molecule is unknown certainly none of the bioassay systems described in Chapter 5, Vol. 1, point to a different role or mechanism of action for this retinoid as compared to retinoic acid. 

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