Retinal pigment epithelial tear

Combination studies Bevacizumab has been combined with photodynamic therapy with verteporfin in a randomized study [2 ]. One patient had a reduction of 20 letters and one had a retinal pigment epithelial tear with a light dose of 12 J/m. ... 

Sensory systems Adverse reactions have been reported from unapproved intravitreal use. These reactions included infectious endophthalmitis, intraocular inflammation (such as sterile endophthalmitis, uveitis, and vitritis), retinal detachment, retinal pigment epithelial tears, increased intraocular pressure, and intraocular hemorrhage (such as vitreous hemorrhage or retinal hemorrhage and conjunctival hemorrhage) [197, 198 ]. Vitreous hemorrhage has also been reported during treatment with bevacizumab for metastatic rectal cancer [199 ]. 

Comparative studies Adverse reactions have been studied in 32 patients with exudative age-related macular degeneration who received standard fluence photodynamic therapy with verteporfin at baseline and months 3, 6, and 9 and ranibizumab 0.5 mg at baseline and months 1, 2, and 3 [5 ]. The main adverse reactions outcome measure was severe loss of vision (a loss of best-corrected visual acuity of at least 30 letters). There was no severe loss of vision due to ocular inflammation or uveitis. One patient had moderate loss of vision (of at least 15 letters). Three patients had mild/moderate uveitis. There were two serious ocular adverse events (a retinal pigment epithelial tear and a moderate reduction in best-corrected visual acuity). There were no systemic adverse events. 

Retinal pigment epithelium tears can complicate exudative age-related macular degeneration or its treatment. An 81-year-old woman with retinal angiomatous proliferation and pigment epithelial detachment had a retinal pigment epithelial tear 10 days after an intravitreal injection of ranibizumab [12 ]. 

Pece A, Isola V, Milan P. Retinal pigment epithelial tear after intravitreal ranibizumab (Lucentis ) for retinal angiomatous proliferation (RAP) associated with pigment epithelial detachment. Semin Ophthalmol 2009 24 210-3. 

Kim SW, Oh J, Oh IK, Huh K. Retinal pigment epithelial tear after half fluence PDT for serous pigment epithelial detachment in central serous chorioretinopathy. Ophthalmic Surg Lasers Imaging 2009 40 300-3. 

---