Retention of Glycoproteins within the ER

Several strategies have been developed to humanize the glycosylation patterns of proteins generated in transgenic plants. The first discussed here is the retention of glycoproteins within the ER. 

Biopharmaceuticals in Plants Toward the Next Century of Medicine 

FIGURE 5.2 (a) Processing of proteins within the ER. Cleavage of signal pep- 

2 Development of Plants that Lack P(1,2)-Xylose and Core a(1,3)-FucosE 

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