Resveratrol binding sites

The affinity of polyphenols and various resveratrol analogs to compete for specific [3H]-resveratrol binding correlated very well (r = 0.74) with their neuroprotective activity against Ap25 35-induced toxicity in primary hippocampal cell cultures. This suggests that the neuroprotective effect exerted by these phenolic compounds could be mediated by a common mechanism involving specific polyphenol plasma membrane binding sites. 

The ligand-binding sites of P-LG, including all the external sites as well as the internal cavity, are solvent-accessible. Resveratrol bound to the outer surface near Trpl9-Argl24 is in a less hydrophobic environment compared to 75% ethanol. With the tip of the isoprene tail protruding from the... 

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