Respiratory disorders, Parkinson

The principal manifestations of phenothiazine toxicity involve the CNS and cardiovascular system. Signs of CNS toxicity include sedation, coma, respiratory depression (uncommon), seizures, hypothermia or hyperthermia, and extrapyramidal movement disorders (acute dystonia, parkinsonism, akathisia, tardive dyskinesia, and neuroleptic malignant syndrome) the extrapyramidal symptoms result from an imbalance between inhibitory dopamine and... 

Because of its potent anticholinergic properties, thioridazine shonld be used cautiously in patients with cardiac diseases snch as congestive heart failure, arrhythmias, angina pectoris, or heart block in encephalitis, Reye s syndrome, head injnry, respiratory disease, epilepsy and other seizure disorders, glaucoma, prostatic hypertrophy, urinary retention, Parkinson s disease, and pheochromocytoma because the drug may exacerbate these conditions and in hypocalcemia because it increases the risk of extrapyramidal reactions. 

Bravi, D., Anderson, J.J., Dagani, F., Davis, T.L., Ferrari, R., Gillespie, M. and Chase, T.N. (1992) Effect of aging and dopaminomimetic therapy on mitochondrial respiratory function in Parkinson s disease. Mov. Disord. 1 228-231. 

L. inflata L. is a traditional medicinal plant native to North America. It contains several piperidine alkaloids. The main alkaloid is lobeline which has a stimulatory effect on the respiratory center and it is applied in the cases of asthma, gas- and narcotic-poisoning. Thus, lobeiine is currently the subject of renewed interest for the treatment of drug abuse and neurological disorders, like Alzheimer s or Parkinson s disease, which pose an important public health problem in industrial countries. As lobeiine can act as a competitive nicotinic receptor antagonist, it is frequently used in antismoking preparations. Interest in Lobelia alkaloids, and in particular (-)-lobeline, the most active of them, has increased in recent years due to their activity on the central nervous system (CNS). 

---