Respiratory devices design

Peart, J. Magyar, C. Byron, P.R. Aerosol electrostatics— metered dose inhalers (MDIs) reformulation and device design issues. In Respiratory Drug Delivery VT, Dalby, R.N., Byron, P.R., Farr, S.J., Eds. Interpharm Press Buffalo Grove, IL, 1998 227-233. 

DeYoung L. The AeroDose multidose inhaler device design and delivery characteristics. Presented at Respiratory Drug Delivery VI, Hilton Head, EL, 1998. 

DeYoung L. The Aerodose multidose inhaler—device design and delivery characteristics. In Respiratory Dmg Delivery VI Dalby RN, Byron PR, Farr SJ, eds. Interpharm Press Hilton Head, SC, 1998 91-96. 

Shade, D. and A. T. Johnson, 2003, Design of respiratory devices, in Standard Handbook of Biomedical Engineering Design, M. Kutz, ed., McGraw-Hill, New York. 

The designer of respiratory devices is, in many ways, faced with the same challenges as designers of other medical devices. There are many different aspects to consider, with device function being but one of these. In addition to device performance, there are safety, user interface, legal, biocompatibility, marketing, cost, and adaptability issues to face. 

Saliva can carry disease organisms. To minimize the transmission of disease, disposable cardboard mouthpieces are used with many respiratory measurement devices. Respiratory devices should, if possible, be designed to include sterilizable parts in the airflow path. This would reduce the possibility that microbes hitchhiking on aerosol particles would be passed from patient to patient. When appropriate, disposable Alters may also help prevent microbe transmission. 

Aesthetic design is important for device acceptance. Many respiratory devices are relatively smalt, and compacmess is usually a positive attribute. There was a time when the very size and massive... 

A protective device for the human respiratory system designed to protect the wearer from inhalation of harmful air contaminants. There are two types of respiratory protective devices (a) air purifiers, which remove the contaminants from the air... 

Protective devices for the human respiratory system designed to protect workers from over-exposure by inhalation of air contaminants (air-purifying and air-supplied) and oxygen deficiency (air-supplied). See also Respirator. 

In Section 3.5.3, dry powder inhalers have been referred to as breath-controlled devices. The efficacy of dry powder inhalation is a function of many factors, influencing the delivered dose of fine particles and the deposition of these particles in the respiratory tract. Figure 3.4 shows that DPI performance is influenced both directly and indirectly by the design of the inhalation system. The powder formulation, the dose (measuring) system and the powder disintegration principle have to be designed correctly for release of sufficient fine drug particles in... 

---