Reproductive/developmental studies

Of 50 adult rats used in a reproductive/developmental study, 22% of those that received 6 mg/kg/day heptachlor in the diet developed lens cataracts 4.5-9.5 months following exposure. In addition, 6-8% of the pi offspring and 6% of the p2 offspring of these rats also developed cataracts 19-21 days after birth (Mestitzova 1967). The author of this study eliminated the possibility of a vitamin B deficiency or a recessive genetic trait as the cause of the cataracts. She could not rule out the possibility of altered vitamin B metabolism caused by heptachlor. 

Checkhst to Determine Whether a Multigeneration Reproduction or Reproductive/Developmental Study is 8(e) Reportable 8e Checklist Multirep and Repdev... 

Appel MJ, Waalkens-Berendsen DH (2004b) Trichlorooctyl-stennane [CAS 3093-25-6] Sub-chronic (13 week) oral toxicity study in rats, including a reproduction/developmental screening study. Zeist, TNO Nutrition and Food Research Institute, July (TNO Report No. V3963). 

Combined repeated dose toxicity study with the reproduction/developmental toxicity screening test OECD... 

Ladies, G.S., et al., Developmental Toxicology Evaluations - Issues with including neurotoxicology assessments in reproductive toxicology studies, Toxicol. Sci., 88, 24, 2005. 

SOT sunset session Developmental toxicology Issues with including neurotox and immunotox assessments in reproductive toxicology studies. New Orleans, LA March, 2005... 

Developmental and reproductive toxicity studies regarding animal exposure to phosgene were not available. 

Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test (Original Guideline, adopted 22 March 1996)... 

The combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) is, for the repeated dose toxicity part, concordant with the standard 28-day oral toxicity study (OECD TG 407) except for use of pregnant females and longer exposure duration (about 6 weeks for males and approximately 54 days for females) in the combined study compared to the standard 28-day study. 

Other types of reproductive toxicity studies, e.g., the prenatal developmental toxicity study, the reproduction/developmental toxicity screening study, and the developmental neurotoxicity study (Section 4.10.3) may give some indications of general toxicological effects arising from repeated exposure over a relatively limited period of the animal s life span as clinical signs of toxicity and... 

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